GPX4 and hepatocellular carcinoma: DSF can raise the level of reactive oxygen species (ROS) and downregulate the protein level of glutathione peroxidase 4 (GPX4) to induce ferroptosis in glioblastoma, and this phenomenon can be rescued by the ferroptosis inhibitor ferrostatin-1.25 It was also reported that the DSF/Cu complex suppresses the cell viability, migration, invasion, and angiogenesis of hepatocellular carcinoma (HCC) cell lines.