PRL and Menkes disease: Namely, in the PrL and IL, overall PNN + staining intensity (GLM, control = 26.30 ± 14.71 vs. MD = 23.45 ± 9.84, n = 5, p < 0.001 and control = 20.73 ± 9.03 vs. MD = 15.65 ± 4.96, n = 5, p < 0.001 respectively), as well as the intensity of PNNs surrounding PV + neurons (GLM, control = 25.70 ± 15.91 vs. MD = 22.73 ± 7.48, n = 5, p < 0.001 and control = 21.81 ± 10.77 vs. MD = 15.79 ± 5.81, n = 5, p < 0.001, respectively) were significantly reduced in young adult male MD rats when compared to controls, while no differences were observed in the roCg1 (Figures 4A–C).