AFP and hepatocellular carcinoma: Interestingly, the sensitivity and specificity of the combined miRNA panel miR-29a, miR-29c, miR-133a, miR-143, miR-145, miR-192, and miR-505 were significantly higher than the sensitivity and specificity of the established biomarker AFP regarding detection of small (AUC: 0.833 vs. 0.727) and early-stage HCC (AUC: 0.824 vs. 0.754).