IGFBP7 and hepatocellular carcinoma: Moreover, specific hypomethylation of the long interspersed nuclear element-1 (LINE-1) (91), methylation of the insulin-like growth factor-binding protein 7 (IGFBP7) gene (92) and hypomethylation of the promotor region of the transcriptional repressor CTCFL were associated with reduced survival in HCC patients (93).