One study identified an HCC-specific exosomal protein profile that included CD44, cell division cycle 42 (CDC42), RAS related protein (RRAS), MET, G protein subunit alpha 13 (GNA13), metalloproteinase domain 1 (ADAM1), GNAS complex locus (GNAS), eukaryotic translation initiation factor 4A3 (EIF4A3) and S100 family proteins (226). Here, GNA13 is linked to hepatocellular carcinoma.