However, a study reported that renal cell carcinoma (RCC) with a high expression of LDHA showed significant multiplication of T cells (including CD3+, CD8+, and Foxp3+ T cells) and decreased effector molecules (granzyme B and perforin) in these tumor-infiltrating T cells (72), suggesting that RCCs are infiltrated by functionally inactive cytotoxic T cells. This evidence concerns the gene PRF1 and renal cell carcinoma.