Univariable and multivariable logistic regression analysis firstly identified tumor c (odds ratio [OR], 0.361; 95% CI: 0.158, 0.826; P = 0.02) and serum AFP levels over 20 ng/mL (OR, 8.117; 95% CI: 2.422, 27.199; P = 0.001) as two independent predictors of GPC3-positive HCCs (Table 4). Here, AFP is linked to neoplasm.