Table 1 summarizes the characteristics of NGS vs. NGF techniques for MM MRD measurement. The choice of NGS and/or NGF for MM MRD evaluation nowadays just depends on the availability of the laboratory (23, 32, 33), and a hybrid approach, that permits to simultaneously assess MRD by looking at both molecular and cellular characteristics of myeloma clones, could be of great help when appliable (34, 35). The gene discussed is NGF; the disease is Miyoshi myopathy.