NGF and plasma cell myeloma: Table 1 summarizes the characteristics of NGS vs. NGF techniques for MM MRD measurement. The choice of NGS and/or NGF for MM MRD evaluation nowadays just depends on the availability of the laboratory (23, 32, 33), and a hybrid approach, that permits to simultaneously assess MRD by looking at both molecular and cellular characteristics of myeloma clones, could be of great help when appliable (34, 35).