GPX4 and leukemia: For patients with immune activation phenotype, we can induce ferroptosis in leukemia cells by stimulating immune cells such as CD8+ T cells to secrete more INF-γ, and inhibit the expression of ferroptosis inhibitors such as GPX4 and DHODH. For immunosuppression phenotype, we can induce ferroptosis by targeting enhanced lipid peroxidation.