It has been reported in the literature that PD-L1, CTLA-4, IDO1, LAG3, HAVCR2, PD-1, PD-L2, CD80, CD86, TIGIT and TNFRSF90 are considered immune checkpoint-related genes (40); TNF, IL6, IFNG, IL1A, IL1B, IL3, CSF2, TGFB1, IL10, ILRN, and IL2A are considered to be cytokines related to inflammation associated with AML (52); TGFB2, ITGAM, VCAM1, CDH1, CDH2, CDH5, PTPRC, SDC1, GJA1, SLC7A5, CXCR4, PTK2, PTK2B, and ILK are considered to be cell adhesion molecules associated with AML (53). This evidence concerns the gene TNF and acute myeloid leukemia.