Results indicate that RRM2 was significantly overrepresented in immune-related pathways, specially, immunoregulatory interactions between lymphoid and non-lymphoid cell pathways are a notable immune-related pathway that modify the response of lymphoid cells to self, tumor, and pathogen antigens (Cemerski & Shaw, 2006; Nedvetzki et al., 2007). The gene discussed is RRM2; the disease is neoplasm.