Sans et al. (2019) reported that the knockdown of CIDEA in obese mice significantly reduced the accumulation of lipid droplets in hepatocytes and thus alleviated HFD-induced hepatic steatosis. In this study, the mRNA of CIDEA was upregulated with 106-fold change and hypermethylated with approximately 242-fold change in HFD group. Although other candidate genes were also hypermethylated to different degrees, the changes were less than CIDEA. Therefore, the most hypermethylated NAFLD-associated gene CIDEA was selected for our subsequent research. Here, CIDEA is linked to metabolic dysfunction-associated steatotic liver disease.