NF-κB, a pro-oncogenic factor in NAFLD-HCC development, is also activated in injured hepatocytes to upregulate transcription of inflammatory cytokines, whose increased expressions further activate the downstream NF-κB signal pathway, forming positive feedback that aggravates inflammation and lipid deposition in liver (Wang et al., 2020). This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.