Yao et al. (2014) created a nomogram to predict the risk of AL after laparoscopic anterior resection, including preservation of the left colonic artery, operation time, and tumor location. The prospective study of Hoshino et al. (2018) reported the independent risk factors of AL were preoperative serum albumin, gender, simultaneous resection of other organs, and tumor diameter and location, and established a nomogram to predict the risk of AL after anterior resection. This evidence concerns the gene ALB and neoplasm.