Such differences may be related to epigenetics (Parrish et al., 2020; Procknow and Kozel, 2022), or some individuals may initially have undetected arterial stenosis then undergo self-healing, suggesting that pulmonary artery stenosis caused by elastin depletion has a high probability of undergoing gradual improvement as reported by Collins et al. (2010). This evidence concerns the gene ELN and Pulmonary artery stenosis.