Figure 2A is a box plot of the 30 DE-SRPGs. Notably, all 30 DE-SRPGs were downregulated in SSc-PH. Subsequently, we verified the expression patterns of the DE-SRPGs in the test set. Due to platform differences, the expressions of RPL10, RPL13A, RPL21, RPL23, RPL4, and RPSA were missing in the test set (GSE22356) among the 30 DE-SRPGs. In the test set, all 24 DE-SRPGs were also significantly downregulated in SSc-PH, except for 6 DE-SRPGs that were missing due to platform differences (Figure 2B, Supplementary Table S3). The gene discussed is RPL4; the disease is systemic sclerosis.