NPPB and systemic sclerosis: Meanwhile, the Australian Scleroderma Interest Group developed the ASIG algorithm for screening SSc-PH based on NT-proBNP levels and lung function test results, which yielded sensitivity, specificity, positive predictive value, and negative predictive value of 94.1%, 54.5%, 61.5%, and 92.3%, respectively (Thakkar et al., 2013).