CXCL8 and systemic sclerosis: Among the 14 SSc-PH-related pathways, complement and coagulation cascades, complement system, endothelin, interleukin-1, interleukin-8, and osteopontin were significantly upregulated while immunoglobulin was significantly downregulated in SRPcluster B compared with SRPcluster A (Figure 6A).