Multiple pathway such as Wnt and JAK-STAT3 signaling has been activated in tumor development and metastasis induced by iron overload (Ebina et al., 1986; Hann et al., 1991; Brookes et al., 2008; Xue et al., 2016; Schwartz et al., 2021), while iron depletion led to suppression of tumor growth and metastasis (Torti et al., 2018). The gene discussed is STAT3; the disease is neoplasm.