A prospective study by Jin et al. (15) included 105 patients with severe traumatic brain injury (GCS 3–8) and 105 healthy subjects, and found that serum Cyp A levels were often elevated in patients with severe traumatic brain injury, and its level was negatively correlated with GCS scores(r = −0.562, P < 0.001), which was an independent risk factor for death and poor prognosis (Glasgow Outcome Scale score of 1–3) after 90-day follow-up. The gene discussed is ACYP2; the disease is brain injury.