Many studies have recently reported that MUC4 and MMP7 are expressed differentially in biopsies of gingival tissue taken from periodontitis patients and healthy controls investigated through RNA sequencing [11].Here, we report, to the best of our knowledge, very first time exploring significantly different levels of the above mentioned two proteins in saliva and GCF samples from patients with periodontitis compared to healthy controls. Here, MUC4 is linked to periodontitis.