In the sensitivity studies, patients with active psoriasis showed extensively increased levels of IL-17A, IL-23, and IL-22 as compared to the group of patients with stable psoriasis [11].The psoriasis lesional skin transcriptome studies have revealed a better understanding of activated cellular pathways within lesions which can help in designing new disease mechanism and possible drug targets [8] butchanges in mRNA expression alone cannot reflect protein abundance [12-15]. This evidence concerns the gene IL22 and psoriasis.