Data showed that the fruit extract of Citrullus colocynthis has cytotoxic effect against human melanoma cell lines through inhibition of Bcl2 mRNA expression or by elevating the Bax mRNA expression on human melanoma cell lines (A375) and it also plays arole in prevention of cell proliferation, induction of cell apoptosis and inhibition of cancer stemness property on human melanoma cells. This evidence concerns the gene BCL2 and cancer.