Also therapeutic targeting of these proteins such as mTOR, Topoisomerase, BCL-2, PTK, H-Ras and PI3k by lupeol have a long way in alleviating disease caused by deregulation of PI3k, mTOR and PTK pathway such as diabetes mellitus, cardiovascular disorder,autoimmune disorders and neurodegenerative diseases. Here, PTK2B is linked to diabetes mellitus.