Also therapeutic targeting of these proteins such as mTOR, Topoisomerase, BCL-2, PTK, H-Ras and PI3k by lupeol have a long way in alleviating disease caused by deregulation of PI3k, mTOR and PTK pathway such as diabetes mellitus, cardiovascular disorder,autoimmune disorders and neurodegenerative diseases. The gene discussed is HRAS; the disease is diabetes mellitus.