TNF and periodontal disorder: A study on Salivary TNFα in periodontal disease with four study groups detected the highest TNFα levels in group 3, the diabetic group(diabetic status of more than 5 years) with pocket probing depth (PPD) ≥5 mm and clinical attachment loss (CAL) of ≥2 mm in comparison with the control group, the periodontal disease group without associated systemic diseases and the smokinggroup [10].