Activation of this TF makesit transition from a latent cytoplasmic form to a nuclear DNA binding state [1] and has been demonstrated to have a role in the prevention of colon cancer [2] by its inhibition[1-3].This TF is known to selectively inhibit interferon-gamma-induced expression of the chemokine CXCL9 gene in mouse macrophages [4].The growth inhibitory and anti-inflammatory properties of sulindac are possibly due to its ability to reduce prostaglandin synthesis by cyclooxygenase inhibition [2]. The gene discussed is TF; the disease is malignant colon neoplasm.