Along with NF-κB, sulindac has been of interest because of its many roles that includes also as a chemo preventive agent foradenomatous colorectal polyps and colon cancer [25] We show here that sulindac is able to bind specifically to a pocket on NF-κB, a concept that becomes theoretically important for exploring its therapeutic potential[26-29]. This evidence concerns the gene NFKB1 and malignant colon neoplasm.