In addition, the up-regulation of TET3 led to a significant increase in p-AKT (T308), p-AKT (S473), and β-catenin while inhibited the expression of p-GSK3β (Tyr216 + Tyr279) and p-GSK3β (Ser9) in ESCC cells. Here, TET3 is linked to esophageal squamous cell carcinoma.