The qPCR data showed that 7 key genes regulated mitophagy pathway, including casein kinase II subunit alpha (csnk2a), sequestosome-1 (p62), Bcl-2 nineteen kilodalton interacting protein 3 (bnip3), autophagy-related gene 9A (atg9), TBC1 domain family member 15-like isoform X2 (tbc1d15), microtubule-associated proteins 1A/1B light chain 3A (lc3a) and FUN14 domain-containing protein 1 (fundc1) were also significantly upregulated in the HD group (p < 0.05; Figure 6B), which was significantly consistent with the RNA-seq data (r = 0.872, p = 0.010; Figure 6C). Here, MAP1LC3A is linked to Huntington disease.