Fasting insulin and glucose measurements can be used to calculate indices such as the homeostatic model assessment of insulin resistance (HOMA-IR), which can approximate parameters such as peripheral and hepatic insulin sensitivity hepaSI as would be assessed in clamp studies or frequently sampled intravenous GTTs (FSIVGTT), a silver standard (Matthews et al., 1985; Bergman et al., 1987; Yeckel et al., 2004). This evidence concerns the gene INS and Insulin resistance.