TP53 and amyotrophic lateral sclerosis: On the other hand, differentially expressed pathways in the disease group involved pantothenate and coA biosynthesis, biosynthesis of unsaturated fatty acids, amyotrophic lateral sclerosis, the Toll-like receptor signaling pathway, the P53 signaling pathway, apoptosis, snare interactions in vesicular transport, the TGF beta signaling pathway, and the NOD-like receptor signaling pathway, while in the healthy group, linoleic acid metabolism was the only differentially expressed pathway (Figure 1(b)).