We found that the enrichment score of the linoleic acid metabolism pathway in the MetS samples was markedly lower than that in the healthy controls, suggesting the dysregulation of the linoleic acid metabolism pathway in MetS, and JMJD7-PLA2G4B, PLA2G1B, PLA2G2D, CYP2C8, and CYP2J2 involved in the pathway were significantly downregulated. This evidence concerns the gene PLA2G2D and metabolic syndrome.