We demonstrated activation of the JNK signaling pathway on exposure to vincristine, and MAPK signaling pathways have a key role in neurodegenerative diseases, such as Parkinson disease, Alzheimer disease and amyotrophic lateral sclerosis (Jin and Zheng, 2019; Obergasteiger et al., 2018). This evidence concerns the gene MAPK8 and early-onset autosomal dominant Alzheimer disease.