The Janus kinase-signal transducer and transcriptional activator (JAK-STAT) signaling pathway is strongly associated with many immune and inflammatory diseases, At present, more and more studies have found that the JAK-STAT pathway is involved in the development and development of epilepsy, indicating the JAK-STAT pathway’s potential promise as a target in epilepsy treatment. The gene discussed is SOAT1; the disease is epilepsy.