In addition, clinical (Costa et al., 2019) and animal (Harnisch et al., 2019) studies on multiple sclerosis have shown that BMP4 is strongly overexpressed in microglia/macrophages at the inflammatory lesion site, indicating that microglia/macrophage-originated BMP4 may be highly correlated with inflammation in the CNS. This evidence concerns the gene BMP4 and multiple sclerosis.