ANXA1 and ischemic stroke: We have provided convincing evidence that SIRT5 acts as a desuccinylase to mediate ANXA1 desuccinylation, thereby promoting ANXA1 translocation to the nucleus and decreasing its membrane transport and extracellular secretion, resulting in the hyperactivation of microglia and the overrelease of proinflammatory cytokines and chemokines, ultimately leading to neuronal cell damage after ischaemic stroke (Fig. 10).