PECAM1 and diabetes mellitus: Consistent with previous results (Fig. 4E, F), diabetes induced angiogenesis, ruptured blood vessels and fibrinogen deposition in diabetic mice (CD31: 20.73; fibrinogen: 14.42, Student’s t test P = 0.0015) in comparison to ND mice (CD31: 16.51 ± 2.565; fibrinogen: 0.6982 ± 0.4107) (Fig. 5H–J).