TNIP2 and obesity due to melanocortin 4 receptor deficiency: However, in a different study, Lou et al. demonstrated that inhibition of miR-15a prevented the activation of NF-κB signaling by inversely regulating TNFAIP3 Interacting Protein 2 (TNIP2) expression in both in vitro and in vivo inflammatory models, although analysis for the inhibition of miR-15a in obesity-related low-grade chronic inflammation has not been reported to date [136].