RAC1 and serum lipopolysaccharide activity: In addition, Targeting Rac1 signaling has been demonstrated to exert anti-inflammatory effects in models of reperfusion injury, endotoxemia, and acute pancreatitis [38], and TIAM1 affects cell migration by activating Rac1, Tanshinone IIA, and Tetramethylpyrazine are the main chemical components of Jiawei Danshen Decoction.