PDCD1 and colorectal cancer: On the other hand, the depletion of METTL3 or METTL14 tumors increased the infiltration of cytotoxic CD8+ T cells and elevated secretion of interferon-gamma (IFN-γ), CXCL9, and CXCL10 in the TIME, thus enhancing the reaction to anti-programmed cell death protein 1 (PD-1) treatment in pMMR-MSI-L colorectal cancer (CRC) [101].