Immunohistochemical detection of the Ki-67 index is an independent factor affecting the prognosis of CRC, and high Ki-67 staining is strongly associated with a poor prognosis in CRC, is positively correlated with CRC invasion depth, lymph node metastasis, and tumor differentiation, and is an independent predictor of prognosis that can be used to stratify patients [5]. The gene discussed is MKI67; the disease is metastatic malignant neoplasm in the lymph nodes.