Moreover, it was formerly reported to decrease the immobility duration time in the forced swimming test, increase serotonin (5-HT) and BDNF levels, and ameliorate symptoms of depression probably due to its ability to block the postsynaptic 5-HT3 receptors, resulting in a decrease in the 5-HT turnover rate [11–13]. Here, BDNF is linked to major depressive disorder.