Regardless, shRNA knockdown experiments with validated constructs against SOX4 (three constructs) and BACH2 (one construct) did not yield consistent results in human AML cell lines with recombined MLL locus (MV-4-11, THP-1, and NOMO-1) (Fig. S7A, C and data not shown). Here, BACH2 is linked to acute myeloid leukemia.