Using IFN-γ induction, we replicated the basal or apical extrusion in KPIC PDAC organoids and found that inhibiting IFN-γ induced IDO-1 in KPIC PDAC organoids with INCB24360 decreased basal extrusion and EMT while promoting the metastasis of subcutaneous KPIC organoids tumor to the liver, indicating the unusual dual status of IDO-1 in tumorigenicity and metastasis of PDACs. This evidence concerns the gene IDO1 and neoplasm.