Comparing proteomics of the IFN-γ + INCB24360 group with other groups, we found that Claudin-3, a Zonula occludens, and inhibitor of carcinoma metastasis [41, 42], was dramatically reduced in IFN-γ + INCB24360 and INCB24360 treated KPIC PDAC organoids (Supplementary Fig. S6c). Here, IFNG is linked to carcinoma.