Less clearly, Notch activity was upregulated in murine-derived HCCs with triple knockout of retinoblastoma protein (RB) and two related RB family members, p107 and p130 [192], but after a pan-Notch blockade was performed, accelerated development of HCC and elevated expression of Notch-related genes were associated with a good prognosis of HCC. Here, RB1 is linked to hepatocellular carcinoma.