When combining site and signature, the shortest median distances were observed in HRD-Dup adnexa and bowel samples, particularly in the activated/predysfunctional and dysfunctional T cell compartments (Fig. 6b and Extended Data Fig. 14b), supporting PD-L1 as a negative feedback mechanism in response to activated T cells in HRD tumours. This evidence concerns the gene CD274 and neoplasm.