PTPRC and cancer: Patient samples were profiled using scRNA-seq on CD45+ and CD45− flow-sorted fractions (Supplementary Table 2), haematoxylin and eosin (H&E) staining and multiplexed immunofluorescence (mpIF) on fixed tissue sections, clinical tumour–normal sequencing of 468 cancer genes by MSK-IMPACT and whole-genome tumour–normal sequencing (Extended Data Fig. 1a,b and Methods).