Mutational signature inference from WGS data yielded 16 HRD-Dup, 6 HRD-Del and 14 FBI tumours (Extended Data Figs. 1b and 2b,c and Supplementary Tables 1 and 3), with model features consistent with previous reports5 (Extended Data Fig. 2d,e), stable across multiple computational methods18,19 and in agreement with BRCA1 and BRCA2 mutations and clinical HRD testing (Extended Data Fig. 2b). The gene discussed is BRCA2; the disease is neoplasm.