Beyond gene alterations, patients stratify by endogenous mutational processes3,16 as inferred from structural variation patterns in whole-genome sequencing (WGS), including HRD subtypes (BRCA1-associated tandem duplications, HRD-Dup; BRCA2-associated interstitial deletions, HRD-Del), CCNE1 amplification-associated foldback inversion (FBI)-bearing tumours and CDK12-associated tandem duplicator (TD)-bearing tumours5,6. This evidence concerns the gene CCNE1 and neoplasm.