These proteins have been reported to play a crucial role in numerous pathways of cancer metastasis as shown in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway maps, namely nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, ErbB signaling pathway, PI3K-Akt signaling pathway, vascular endothelial growth factor (VEGF) signaling pathway, and adherens junctions19. This evidence concerns the gene AKT1 and cancer.