First, we evaluated the cytotoxic effect of aminobenzothiazole derivatives on normal human fibroblast cell line (HSF) and four human adenocarcinoma cell lines with various p53 status (wild type: A549; mutant: MIA PaCa-2 p53(R248W), OVCAR-3 p53(R248Q); and knockout: MCF-7 p53(−/−)). This evidence concerns the gene TP53 and adenocarcinoma.