Among these thirteen loci associated with HF subtypes, seven loci (NFIA, E2F6, MITF, PHACTR1, METTL7A, PNMT, and BPTF) have not been reported in previous HF-related GWAS, of which four loci (NFIA, MITF, PHACTR1, and METTL7A) were GWS only in GWAS of HFrEF cases. The gene discussed is MITF; the disease is hydrops fetalis.