Among MVP African Americans, all but two of the SNPs identified in the GWAS of unclassified HF in the European ancestry had genetic associations with unclassified HF in the same direction, and two (rs3176326-CDKN1A and rs12150603-PNMT) were significant after Bonferroni correction (Supplementary Data 4); four (rs4717903-GTF2I, rs12933292-NFAT5, rs1002135-SMG6, and rs1999323-MAP3K7CL) were replicated in the recent HF GWAS8 after Bonferroni correction. The gene discussed is SMG6; the disease is hydrops fetalis.