Some examples of such robust hits include KEAP1-TAPT1 in lung cancer - a dependency recently established by Romero et al.59, EIF3C-MTOR in pancreatic cancer (Supplementary Data 2, 3), ARID1A-TEAD1, ARID1A-FERMT2, and AXIN1-URI1 in hepatocellular carcinoma (Figs. 3c, 4, 5; Supplementary Figs. 4, 5), and GATA3-MDM2 in breast cancer. This evidence concerns the gene MDM2 and familial pancreatic carcinoma.