One promising approach has been based on observed network alterations throughout the brain3,4,8, such as decreased connectivity in precuneus, parahippocampal gyrus, thalamus and post central gyrus9, as well as white matter disruptions10, in addition to Aβ and tau patterns5, which led to conceptualizing AD as a “circuitopathy”11. The gene discussed is MAPT; the disease is Alzheimer disease.