FCGR3A and infection: FcγRIIIa-binding antibodies are associated with antibody-dependent cell cytotoxicity, clearance of immune complexes and killing of infected cells, thereby contributing to protection from severity during breakthrough Omicron infections.30,31 These FcγR antibodies increased significantly in adolescents and adults following two doses of BNT162b28 but had not been assessed following three doses in adults or adolescents.