Streptococcus gallolyticus (S. gallolyticus) plays a role in promoting TMEs as it generates an immunosuppressive microenvironment.64 Besides, S. gallolyticus-infected patients have elevated mRNA expression of pro-inflammatory markers such as NF-κB and IL-8.59 Therefore, further investigation is needed of the S. gallolyticus subspecies involved in CRC. The gene discussed is NFKB1; the disease is colorectal carcinoma.