MAPK3 and neoplasm: - Immunomodulation via regulation of AhR- Rebalance gut microbiota diversity and composition- Inhibit NF-kB and activate apoptosis- Antitumor effect via modulation of Tc17 cells and CTLs- Inhibit ERK1/2, causing tumor growth disruption- Induce ROS activity and decrease glucose oxidation- Induce HDAC