KRAS and lung adenocarcinoma: Oncogenic KRas activates mitochondrial fission through Erk2-mediated phosphorylation of Drp1,12,13 and inhibition of mitochondrial fission inhibits KRas-driven glycolytic flux, cellular transformation, and pancreatic tumor (PDAC) growth.14 To determine if mitochondrial fission contributes to tumor growth in other Ras-driven malignancies, we explored the effects of mitochondrial dynamics disruption in KRas-driven lung adenocarcinoma (LUAD).