SIRT7 and obesity due to melanocortin 4 receptor deficiency: Given the association of sirtuins to known risk factors of NAFLD, such as diet, obesity, and NAD+, the prominent NAFLD phenotype in the SIRT7−/− mouse model,26–28 and the observation that SIRT7 prevents the development of NAFLD by suppressing ER stress,27 a major driver of the progression from NAFLD to NASH,22 the SIRT7−/− mouse model is relevant to human NASH, although human genome-wide association study (GWAS) data linking SIRT7 to NAFLD have not emerged yet.