SIRT7 and metabolic dysfunction-associated steatohepatitis: The livers of SIRT7−/− mice exhibited increased inflammation (Figures 4A and 4B), apoptosis (Figures 4A and 4C), proliferation (Figures 4A and 4D), and fibrosis (Figures 4A and 4E), characteristic of the cellular and pathophysiological features of NASH.21,34–37 The analysis of the single-cell RNA sequencing data for the livers of wild-type and SIRT7−/− mice revealed increased expression of cell-cycle genes in hepatocytes of SIRT7−/− mice, consistent with increased proliferation of hepatocytes as a way to repair damage and restore loss of mass (Figure S5).