This type of rolling behavior has previously been observed when Salmonella disseminates through the bloodstream to the brain.29 Importantly, Atf5ΔIEC mice succumbed to Salmonella infection at a faster rate than control animals (Figure 1L), suggesting that ATF5 plays a pivotal protective role in the intestinal epithelium to protect the host during enteric infection. This evidence concerns the gene ATF5 and Salmonella Infections.