Although injection of JQ1 alone reduced tumor growth and downgraded c-Myc expression in the xenograft model, this epigenetic BET inhibition had only a trivial effect on altering BRD4 and HIF-1α protein levels, in contrast to our ENCTAC compounds, indicating a different mechanism for suppressing the tumor response to hypoxia. The gene discussed is MYC; the disease is neoplasm.