Congruently with the widespread involvement of the adenosinergic system in other neurodegenerative disorders, several studies have shown increased adenosine levels in the cerebrospinal fluid of ALS patients [2], as well as increased A2AR expression in the lymphocytes [3] and post-mortem spinal cord samples of ALS patients [4]. Here, ADORA2A is linked to amyotrophic lateral sclerosis.